Factors Affecting the Response to Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn Infants
نویسندگان
چکیده
منابع مشابه
Inhaled nitric oxide in persistent pulmonary hypertension of the newborn.
Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preduc...
متن کاملClinical response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn.
We observed clinical response to inhaled nitric oxide (iNO) in 12 neonates with persistent pulmonary hypertension of the newborn (PPHN). Clinical response was defined as a decrease in oxygenation index (OI) by 40%. Ten of 12 neonates had response to iNO showing decrease OI from 46.1+/-7.6 to 14.4+/-6.8 at 1 hour after inhalation. Sustained improvement of OI was achieved in 8 neonates and two ne...
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OBJECTIVE. The aim was to determine whether inhaled nitric oxide therapy improves neurodevelopmental outcomes for infants with preterm persistent pulmonary hypertension of the newborn. METHODS.We conducted a historical cohort study to compare the 3-year incidence of cerebral palsy in preterm singleton infants ( 34 gestational weeks) with hypoxemic respiratory failure caused by persistent pulmon...
متن کاملInhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilation
BACKGROUND: This study was designed to evaluate the effect of nitric oxide (NO) on the management of neonates with severe persistent pulmonary hypertension refractory to high-frequency oscillatory ventilation. METHODS: The birth weight and the gestational age of infants were 3125.5 +/- 794 g (mean +/- SD) and 39 +/- 2.4 weeks, respectively. All neonates were ventilated for an average of 137.5 m...
متن کاملInhaled nitric oxide in the management of persistent pulmonary hypertension of the newborn: a meta-analysis.
OBJECTIVES To evaluate the use of inhaled nitric oxide (NO) in the management of persistent pulmonary hypertension of the newborn. METHODS Computerized bibliographic search on MEDLINE, CURRENT CONTENTS and LILACS covering the period from January 1990 to March 1998; review of references of all papers found on the subject. Only randomized clinical trials evaluating nitric oxide and conventional...
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ژورنال
عنوان ژورنال: Yonsei Medical Journal
سال: 2004
ISSN: 0513-5796
DOI: 10.3349/ymj.2004.45.1.49